Pilchardus Study

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Publications

The results obtained by our research team have been presented at important scientific conferences and meetings and have been published in internationally renowned scientific journals.

Below please find a selection of recent publications produced by the Diabetes and Obesity Research Laboratory:

Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state
Moreno P, Acitores A, Gutiérrez-Rojas I, Nuche-Berenguer B, El Assar M, Rodríguez-Manas L, Gomis R, Valverde I, Visa M, Malaisse WJ, Novials A, González N, Villanueva-Peñacarrillo ML.
Peptides 32:2077-85, 2011

Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide
Soty M, Visa M, Soriano S, Carmona MC, Nadal Á, Novials A.
J Biol Chem 286:40857-66, 2011

PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells
Mormeneo E, Jimenez-Mallebrera C, Palomer X, De Nigris V, Vazquez-Carrera M, Orozco A, Nascimento A, Colomer J, Lerin C, Gomez-Foix AM.
PLoS One 7: e29985, 2012

Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome
Vieira E, G Ruano E, C Figueroa AL, Aranda G, Momblan D, Carmona F, Gomis R, Vidal J, Hanzu FA.
PLoS One 9(11):e111678, 2014

Hypothalamic and brainstem neurocircuits controlling homeostatic energy balance
Schneeberger M, Gomis R, Claret M.
J Endocrinol. 220(2):T25-46, 2014

Differential transcriptional and post-translational Transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients
Pradas-Juni M, Nicod N, Fernández-Rebollo E, Gomis R.
Mol Endocrinol. 28(9):1558-70, 2014

Tungstate promotes β-cell survival in Irs2-/-mice
Oliveira JM, Rebuffat SA, Gasa R, Burks D, Garcia A, Kalko S, Zafra D, Guinovart JJ, Gomis R.
Am J Physiol Endocrinol Metab. 306(1):E36-47, 2014

Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity
Malpique R, Figueiredo H, Esteban Y, Rebuffat SA, Hanzu FA, Vinaixa M, Yanes O, Correig X, Barceló-Batllori S, Gasa R, Kalko S, Gomis R.
Diabetologia 57(6):1219-31, 2014

Obesity rather than regional fat depots marks the metabolomic pattern of adipose tissue: An untargeted metabolomic approach
Hanzu FA, Vinaixa M, Papageorgiou A, Párrizas M, Correig X, Delgado S, Carmona F, Samino S, Vidal, Gomis R.
Obesity 22(3):698-704, 2014

Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass
Fernandez-Ruiz R, Vieira E, Garcia-Roves PM, Gomis R.
PLoS One 9(2):e90344, 2014

Differential methylation of TCF7L2 promoter in peripheral blood DNA in newly diagnosed, drug-naïve patientes with type 2 diabetes
Canivell S, Ruano EG, Sisó-Almirall A, Kostov B, González-de Paz L, Fernandez-Rebollo E, Hanzu FA, Párrizas M, Novials A, Gomis R.
PLoS One. 9(6):e99310, 2014

Diagnosis and classification of autoimmune diabetes mellitus
Canivell S, Gomis R
Autoimmun Rev. 13:403–07, 2015

Hypothalamic ER stress: A bridge between leptin resistance and obesity
Ramírez S, Claret M.
FEBS Lett. 589(14):1678-87, 2015

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction.
Zorzano A, Claret M.
Front Aging Neurosci. 7:101, 2015

Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis.
Schneeberger M, Gómez-Valadés AG, Altirriba J, Sebastián D, Ramírez S, Garcia A, Esteban Y, Drougard A, Ferrés-Coy A, Bortolozzi A, Garcia-Roves PM, Jones JG, Manadas B, Zorzano A, Gomis R, Claret M.
Cell Rep. 12(3):361-70, 2015

Emerging concepts in Diabetes: mitochondrial dynamics and glucose homeostasis
Gómez-Valadés AG, Gonzalez-Franquesa A, Pau GP, Claret M, Garcia-Roves PM. Curr
Diabetes Rev. Oct 12. PMID:26456359, 2015

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
Schneeberger M, Everard A, Gómez-Valadés AG, Matamoros S, Ramírez S, Delzenne NM, Gomis R, Claret M, Cani PD
Sci Rep. 5:16643, 2015

Hypothalamic miRNAs: emerging roles in energy balance control
Schneeberger M, Gomez-Valades AG, Ramirez S, Gomis R, Claret M
Front Neurosc. 9:41 (Corrigendum: 20;9:969), 2015

Reduced α-MSH underlies hypothalamic ER-stress-induced hepatic gluconeogenesis
Schneeberger M, Gomez-Valades AG, Altirriba J, Sebastian D, Ramirez S, Garcia A, Esteban Y, Drougard A, Ferres-Coy A, Bartolozzi A, Garcia-Roves PM, Jones JG, Zorzano A, Gomis R, Claret M.
Cell Rep. 12(3):361-70, 2015

Role of sodium tungstate as a potential antiplatelet agent
Fernández-Ruiz R, Pino M, Hurtado B, García de Frutos P, Caballo C, Escolar G, Gomis R, Diaz-Ricart M.
Drug Des Dev Ther. 9:2777-86, 2015

Circulating SFRP5 levels are elevated in drug-naïve recently diagnosed type 2 diabetic patients as compared to prediabetic subjects and controls
Canivell S, Rebuffat S, G Ruano E, Kostov B, Sisó-Almirall A, Novials A, Ceriello A, Gomis R.
Diabetes Metab Res Rev. 31(2):212-9, 2015

Preclinical and clinical studies for sodium tungstate: application in humans
Bertinat R, Nualart F, Yáñez Alejandro J, Gomis R.
J Clin Cel Immunol. 6:285, 2015

The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues.
Altirriba J, García A, Sánchez B, Haba L, Altekruse S, Stratmann T, Bombí JA, Mezquita C, Gomis R, Mora C.
International Journal of Cancer, 130, 2743-2745 (2012)
Article

Expression of TMEM16A and SLC4A4 in human pancreatic islets.
Hanzu FA, Gasa R, Bulur N, Lybaert P, Gomis R, Malaisse WJ, Beauwens R, Sener A.
Cellular Physiology and Biochemistry, 29, 61-64 (2012).
Article

PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells.
Mormeneo E, Jimenez-Mallebrera C, Palomer X, De Nigris V, Vazquez-Carrera M, Orozco A, Nascimento A, Colomer J, Lerin C, Gomez-Foix AM.
PLoS One, 7, e29985 (2012).
Article

Role of IGFBP-3 in the regulation of β-cell mass during obesity: adipose tissue/β-cell cross talk.
Palau N, Rebuffat SA, Altirriba J, Piquer S, Hanzu FA, Gomis R, Barbera A.
Endocrinology, 153, 177-187 (2012)
Article

Sequence and epigenetic determinants in the regulation of the Math6 gene by Neurogenin3.
Pujadas G, Felipe F, Ejarque M, Sánchez L, Cervantes S, Lynn FC, Gomis R, Gasa R.
Differentiation, 82, 66-76 (2011)
Article

Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.
Soty M, Visa M, Soriano S, Carmona MC, Nadal Á, Novials A.
Journal of Biological Chemistry, 286, 40857-40866 (2011)
Article

Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state.
Moreno P, Acitores A, Gutiérrez-Rojas I, Nuche-Berenguer B, El Assar M, Rodríguez-Manas L, Gomis R, Valverde I, Visa M, Malaisse WJ, Novials A, González N, Villanueva-Peñacarrillo ML.
Peptides, 32, 2077-2085 (2011)
Article

Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway.
Amigo-Correig M, Barceló-Batllori S, Piquer S, Soty M, Pujadas G, Gasa R, Bortolozzi A, Carmona MC, Gomis R.
Diabetes, Obesity and Metabolism, 13, 235-242 (2011)
Article

Translational evidence of endothelial damage in obese individuals: inflammatory and prothrombotic responses.
Hanzu FA, Palomo M, Kalko SG, Párrizas M, Garaulet M, Escolar G, Gomis R, Díaz-Ricart M.
Journal of Thrombosis and Haemostasis, 9, 1236-1245 (2011)
Article

Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity.
Mezghenna K, Pomies P, Chalancon A, Castex F, Leroy J, Niclauss N, Nadal B, Cambier L, Cazevieille C, Petit P, Gomis R, Berney T, Gross R, Lajoix AD.
Diabetologia, 54, 2856-2866 (2011)
Article

Glucose and fructose as functional modulators of overall dog, but not boar sperm function.
Fernández-Novell JM, Ballester J, Altirriba J, Ramió-Lluch L, Barberà A, Gomis R, Guinovart JJ, Rodríguez-Gil JE.
Reproduction, Fertility and Development, 23, 468-480 (2011).